Aspergillosis history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
History
- When evaluating a patient for aspergillosis, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and a thorough occupational history. Other specific areas of focus when obtaining the history are outlined below:[1][2]
- Review past medical history for any previous immunodeficient states such as AIDS, hematological cancers, and cystic fibrosis
- Review past medical history for any previous cavitary pulmonary disease such as tuberculosis or sarcoidosis, which may predispose to aspergilloma formation
- Review surgical history for any organ transplantation procedures
- Patients medications review for any immune-suppressive drugs such as chemotherapy and long term corticosteroid use
Symptoms
- The specific clinical presentation of aspergillosis is determined by the exact clinical subtype of the disease such as:[1][2]
- Invasive pulmonary aspergillosis may present with:
- Spiking fever (refractory to antibiotic therapy)
- Pleuritic chest pain
- Cough
- Shortness of breath
- Haemoptysis
- Headache
- Seizures
- Chronic necrotizing aspergillosis may present with:
- Chronic fever (1-6 months)
- Malaise
- Fatigue
- Weight loss
- Chronic productive cough
- Haemoptysis (may be severe)
- Aspergilloma may present with:
- Most patients with aspergilloma are asymptomatic
- Mild haemoptysis (most common symptom)
- Cough
- Dyspnea
- Fever (related to bacterial super-infection)
- Allergic bronchopulmonary aspergillosis (ABPA) may present with:
References
- ↑ 1.0 1.1 Aspergillosis. MAYO CLINIC (2015) http://www.mayoclinic.org/diseases-conditions/aspergillosis/basics/risk-factors/con-20030330 Accessed on February, 8 2016
- ↑ 2.0 2.1 Kousha M, Tadi R, Soubani AO (2011). "Pulmonary aspergillosis: a clinical review". Eur Respir Rev. 20 (121): 156–74. doi:10.1183/09059180.00001011. PMID 21881144.