Aspergillosis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of aspergillosis include positive aspergillus antibody test, positive galactomannan test, and elevated concentration of IgE immunoglobulin.[1][2][3]
Laboratory Findings
Complete Blood Count
- Eosinophilia
Electrophoresis
- Elevated concentration of serum immunoglobulin E (IgE)
Biomarkers
- Positive galactomannan assay
- Positive beta-D-glucan assay
Culture
- Positive sputum culture and stain following bronchoalveolar lavage (BAL)
- Can be done on a variety of sterile specimens and Aspergillus spp. present as rapidly growing molds that are visible 1-3 days after incubation.
- However, patients with invasive aspergillosis may have negative cultures.
References
- ↑ Aspergillosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Aspergillosis#Diagnosis Accessed on February, 8 2016
- ↑ Cuenca-Estrella M, Bassetti M, Lass-Flörl C, Rácil Z, Richardson M, Rogers TR (2011). "Detection and investigation of invasive mould disease". J Antimicrob Chemother. 66 Suppl 1: i15–24. doi:10.1093/jac/dkq438. PMID 21177400.
- ↑ Kradin RL, Mark EJ (2008). "The pathology of pulmonary disorders due to Aspergillus spp". Arch Pathol Lab Med. 132 (4): 606–14. doi:10.1043/1543-2165(2008)132[606:TPOPDD]2.0.CO;2. PMID 18384212.
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