Aspergillosis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Yazan Daaboul, M.D.; Serge Korjian M.D.
Overview
Laboratory findings consistent with the diagnosis of aspergillosis include positive aspergillus antibody test, positive galactomannan test, elevated concentration of IgE immunoglobulin, and positive culture from sputum or bronchoalveolar lavage.[1][2][3]
Laboratory Findings
Complete Blood Count
Electrophoresis
- Elevated concentration of serum immunoglobulin E (IgE)
Biomarkers
- Positive galactomannan assay
- Positive beta-D-glucan assay
Culture
- Positive culture and staining from sputum or from bronchoalveolar lavage (BAL)
- Culture can be performed on a variety of sterile specimens. Aspergillus spp. typically appear as rapidly growing molds that are visible 1-3 days following incubation.
- Patients with invasive aspergillosis may have negative cultures.
References
- ↑ Aspergillosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Aspergillosis#Diagnosis Accessed on February, 8 2016
- ↑ Cuenca-Estrella M, Bassetti M, Lass-Flörl C, Rácil Z, Richardson M, Rogers TR (2011). "Detection and investigation of invasive mould disease". J Antimicrob Chemother. 66 Suppl 1: i15–24. doi:10.1093/jac/dkq438. PMID 21177400.
- ↑ Kradin RL, Mark EJ (2008). "The pathology of pulmonary disorders due to Aspergillus spp". Arch Pathol Lab Med. 132 (4): 606–14. doi:10.1043/1543-2165(2008)132[606:TPOPDD]2.0.CO;2. PMID 18384212.