Hereditary nonpolyposis colorectal cancer medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
There is no medical treatment for hereditary nonpolyposis colorectal cancer.[1][2] However, hereditary nonpolyposis colorectal cancer patients should consider diet optimization and pharmacological prevention.
Medical Therapy
HNPCC patients should consider the following options of medical management:[3]
Diet Optimization
- Persons with high risk of colorectal cancer should consider a low fat diet with limitations concerning red meat. Conversely, dietary approaches should consider the inclusion of high fiber and rich in cellulose foods.
Pharmacological Prevention
- Drugs lowering the risk of colorectal cancer include: aspirin, sulindac, prioxicam, calcium, and vitamin C. The real value of such drugs in cancer prevention in hereditary nonpolyposis colorectal cancer cannot be excluded, but is not proven.[1]
References
- ↑ 1.0 1.1 Si JW, Wang L, Ba XJ, Zhang X, Dong Y, Zhang JX, Li WT, Li T (2015). "[Clinicopathological screening of Lynch syndrome: a report of 2 cases and literature review]". Beijing Da Xue Xue Bao (in Chinese). 47 (5): 858–64. PMID 26474631.
- ↑ Hendriks YM, de Jong AE, Morreau H, Tops CM, Vasen HF, Wijnen JT, Breuning MH, Bröcker-Vriends AH (2006). "Diagnostic approach and management of Lynch syndrome (hereditary nonpolyposis colorectal carcinoma): a guide for clinicians". CA Cancer J Clin. 56 (4): 213–25. PMID 16870997.
- ↑ Kladny J, Lubinski J. Lynch syndrome (HNPCC). Hered Cancer Clin Pract. 2008;6(2):99-102.