Large cell carcinoma of the lung natural history
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
If left untreated, large cell carcinoma of the lung progression occurs rapidly and is then followed by local invasion to chest wall and adjacent lymph nodes.[1] Large cell carcinoma of the lung is a locally aggressive tumor. Large cell carcinoma of the lung is a diagnosis of "exclusion", usually the tumor cells lack light microscopic characteristics that would classify the neoplasm as a small-cell carcinoma, squamous-cell carcinoma, adenocarcinoma, or other more specific histologic type of lung cancer. Large cell carcinoma of the lung commonly occurs in adult patients between 55 to 60 years. Common sites of metastasis include adrenal gland, bone, brain, and liver. Complications of large cell carcinoma of the lung, include: acute respiratory failure, malignant pleural effusion, metastases, and pneumonia. Features associated with worse prognosis are presence of lymphatic invasion, location of lesion, gene expression profile, performance status, presence of satellite lesions, and presence of regional or distant metastases. Prognosis is generally regarded as poor.
Natural History
- If left untreated, large cell carcinoma of the lung progression occurs rapidly and is then followed by local invasion to chest wall and adjacent lymph nodes.[1]
- Large cell carcinoma of the lung is a locally aggressive tumor.
- Large cell carcinoma of the lung is a diagnosis of "exclusion", usually the tumor cells lack light microscopic characteristics that would classify the neoplasm as a small-cell carcinoma, squamous-cell carcinoma, adenocarcinoma, or other more specific histologic type of lung cancer.
- Large cell carcinoma of the lung commonly occurs in adult patients between 55 to 60 years.
- Common sites of metastasis include adrenal gland, bone, brain, and liver
Complications
- Complications of large cell carcinoma of the lung, include:
Prognosis
- Prognosis of large cell carcinoma of the lung is generally regarded as poor
- Features associated with worse prognosis in large cell carcinoma of the lung, include:
- Presence of lymphatic invasion
- Location of lesion
- Poor performance status
- Presence of satellite lesions
- Presence of regional or distant metastases