Fibroma causes
|
Fibroma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Fibroma causes On the Web |
|
American Roentgen Ray Society Images of Fibroma causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Causes
Chondromyxoid Fibroma
There are no established causes for chondromyxoid fibroma. However, scientists have noted an association of chondromyxoid fibroma with certain chromosomal abnormalities. Chondromyxoid fibroma may be caused by a clonal rearrangement of chromosome 6. The oncogene activation resulting from this clonal rearrangement is likely to be involved in the pathogenesis of chondromyxoid fibroma. Scientists have found that the glutamate receptor gene GRM1 recombines with several partner genes through promoter swapping and gene fusion. The subjects with chondromyxoid fibroma also showed increases in GRM1 gene expression levels.[1][2][3]
Oral Fibroma
The oral fibroma is a common oral lesion that arises due to trauma or chronic irritation. The fibroma is considered to be a reactive lesion. Oral fibroma represents a response of connective tissue cells to chronic irritation. When trauma occurs, the tissues of the oral cavity react and an irrepressible repair process is seen. As a result, an overabundance of fibrous connective tissue is produced and the formation of a nodule or mass.
Non-ossifying Fibroma
The cause of non-ossifying fibroma has not been identified.
Cemento-ossifying Fibroma
There are no established causes for cemento-ossifying fibroma. However, there have been reports of past trauma in the area of the lesion.[4]
Ovarian Fibroma
There are no established causes for ovarian fibroma. However, there are several factors that are associated with fibroid growth. These factors include the following:
- Obesity
- Tamoxifen therapy has been associated with an increase in persistent ovarian cysts.
- Early menarche.
- Infertility
- Nulliparity
- African race
- The natural production of estrogen in the body has also been known to be a stimulant of fibroid growth.
References
- ↑ Granter SR, Renshaw AA, Kozakewich HP, Fletcher JA (1998). "The pericentromeric inversion, inv (6)(p25q13), is a novel diagnostic marker in chondromyxoid fibroma". Mod Pathol. 11 (11): 1071–4. PMID 9831204.
- ↑ Yasuda T, Nishio J, Sumegi J, Kapels KM, Althof PA, Sawyer JR; et al. (2009). "Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma". Mod Pathol. 22 (11): 1499–506. doi:10.1038/modpathol.2009.101. PMC 2784180. PMID 19648885.
- ↑ Nord KH, Lilljebjörn H, Vezzi F, Nilsson J, Magnusson L, Tayebwa J; et al. (2014). "GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma". Nat Genet. 46 (5): 474–7. doi:10.1038/ng.2927. PMID 24658000.
- ↑ Silvestre-Rangil, J.; Silvestre, FJ.; Requeni-Bernal, J. (2011). "Cemento-ossifying fibroma of the mandible: Presentation of a case and review of the literature". Journal of Clinical and Experimental Dentistry: e66–e69. doi:10.4317/jced.3.e66. ISSN 1989-5488.