Cryoglobulinemia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
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Overview
History
Symptoms
Symptoms vary depending on the type of disorder and the organs involved. Symptoms of cryoglobulinemia may include:
- Difficulty breathing
- Symptoms related to glomerulonephritis including blood in urine, foamy urine, and edema
- Renal disease occurs in 20% of patients at diagnosis and eventually develops in up to 60%, usually after the development of purpura.
- Renal involvement is more common in Type II than in Type III.
- Purpura or skin ulcer
- Arthralgia
- Myalgia
- Fatigue and other nonspecific constitutional symptoms