Cryoglobulinemia other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Overview

Skin biopsy can be of value in establishing the diagnosis.

The characteristic findings on renal biopsy are
1. Intraluminal thrombi
2. Diffuse IgM deposition in the capillary loops
3. Subendothelial deposits in a “curvilinear” pattern on EM.
Only 14% develop end stage renal disease (ESRD) at 10 years after a renal biopsy demonstrates MC.
Recurrent MC can affect up to 70% of transplanted kidneys, but does not preclude transplantation since most of these grafts do not fail.