Paroxysmal nocturnal hemoglobinuria history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

History and Symptoms

Quite paradoxically, the destruction of red blood cells (hemolysis) is neither paroxysmal nor nocturnal the majority of the time (this constellation of symptoms is seen in only 25% of patients). Patients with PNH manifest the clinical and laboratory signs of chronic hemolytic anemia.

Symptoms of paroxysmal nocturnal hemoglobinuria include:

• Abdominal pain
• Back pain
• Blood clots
• Dark urine
• Easy bruising or bleeding
• Weakness
• Headache
• Shortness of breath