Paroxysmal nocturnal hemoglobinuria MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

MRI

• Renal cortical signal intensity loss (hemosiderin accumulates in the renal cortex when intravascular hemolysis results in the direct release of hemoglobin into the plasma).
• Venous thrombosis.
• Liver and spleen are usually of normal signal intensity in paroxysmal nocturnal hemoglobinuria, unless repeated transfusions have resulted in hepatic and splenic signal intensity loss owing to transfusional siderosis.

(Images shown below are courtesy of RadsWiki)

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