Focal segmental glomerulosclerosis overview
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Differentiating Focal segmental glomerulosclerosis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief:’’’ Cafer Zorkun, M.D., Ph.D. [2]Olufunmilola Olubukola M.D.[3]
Overview
Focal segmental glomerulosclerosis (FSGS) is a cause of nephrotic syndrome in children and adolescents, as well as an important cause of kidney failure in adults.[1] Focal Segmental Glomerulosclerosis (FSGS) is a distinct finding and a descriptive report on the glomerular morphology seen in certain glomerular disease conditions. It is considered to be a glomerular podocytopathy [2]. Minimal change disease (MCD) is by far the most common cause of nephrotic syndrome in children: MCD and primary FSGS may have a similar cause.[1]
The individual components of the name refer to the appearance of the kidney tissue on biopsy: focal - only some of the glomeruli are involved (as opposed to diffuse), segmental - only part of an entire glomerulus is involved (as opposed to global), glomerulosclerosis - refers to scarring of the glomerulus (a part of the nephron (the functional unit of the kidney)).
FSGS is a progressive form of renal disease, it has become the most common cause of GN-related ESRD in patients with End Stage Renal Disease (ESRD) in the United States [3]
References
- ↑ 1.0 1.1 Kumar V, Fausto N, Abbas A (editors) (2003). Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. pp. pp. 982-3. ISBN 978-0-721-60187-8.
- ↑ Sethi S, Glassock RJ, Fervenza FC (2015). "Focal segmental glomerulosclerosis: towards a better understanding for the practicing nephrologist". Nephrol Dial Transplant. 30 (3): 375–84. doi:10.1093/ndt/gfu035. PMID 24589721 PMID: 24589721 Check
|pmid=value (help). - ↑ Kitiyakara C, Eggers P, Kopp JB (2004). "Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States". Am J Kidney Dis. 44 (5): 815–25. PMID 15492947.