Focal segmental glomerulosclerosis historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]
Overview
Historical Perspective
It is believed that Theodor Fahr, a German pathologist, first was first to describe "progressive lipoid nephrosis" in 1925 and to draw an illustration of focal segmental glomerulosclerosis (FSGS).[1] At the time, he referred to it as "lipoid nephrosis with degeneration", showing a clear association to minimal change disease. FSGS was then described in 1957 by Dr. Arnold Rich, a pathologist at Johns Hopkins University.[2] His original article "A hitherto undescribed vulnerability of the juxtamedullary glomeruli in lipoid nephrosis" was originally published in "Bulletin of the Johns Hopkins Hospital".[2] In his original description, he noted the presence of segmental sclerosis in juxtamedullary glomeruli of autopsies of uremic children with nephrosis.[2] In 1970, Jacob Churg and colleagues finally classified FSGS as a unique renal glomerulopathy in the " Pathology of the Nephrotic Syndrome in Children: Report for the International International Study of Kidney Disease in Children" in view of its clinical and pathological features, and its steroid-resistance in comparison to minimal change disease.[3]
References
- ↑ Fahr, T (1925). Pathologische anatomie des morbus brightii. In: Fahr T, Gruber GB, Koch M, et al. eds. Harnorgane Männliche Geschlechtsorgane. Vienna: Springer. pp. 156–472.
- ↑ 2.0 2.1 2.2 RICH AR (1957). "A hitherto undescribed vulnerability of the juxtamedullary glomeruli in lipoid nephrosis". Bull Johns Hopkins Hosp. 100 (4): 173–86. PMID 13426687.
- ↑ Churg J, Habib R, White RH (1970). "Pathology of the nephrotic syndrome in children: a report for the International Study of Kidney Disease in Children". Lancet. 760 (1): 1299–302. PMID 4193942.