Congenital rubella syndrome natural history

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

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Overview

Congenital rubella syndrome can cause serious birth defects and the prognosis depends on the severity of the problem. Heart defects can be corrected but neurological damage is permanent.

Complications

Complications of congenital rubella syndrome include several birth defects, which can result in early and late complications.

Early Complications

Organ System Involved	Complication
HEENT	Microcephaly Congenital cataracts Sensorineural hearing loss
Neurological	Mental retardation Encephalitis
Cardiac	VSD PDA Coarctation of the aorta Pulmonary artery stenosis

Late Complications

Organ System Involved	Complication
HEENT	Glaucoma
Endocrine	Non-insulin dependent diabetes mellitus (NIDDM) Thyroid dysfunction, thyroiditis
Neurological/ Psychiatric	Progressive pan-encephalitis Autism Non-affective psychosis