Amoebic liver abscess differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S[2]

Differential Diagnosis

Amoebic liver abscess must be differentiated from:

Disease	Causes	symptoms											Lab Findings				Imaging Findings					Other findings
		Fever	Pain	cough	Hepatomegaly	Jaundice	Weight loss	Anorexia	Diarrhoea or Dysentry	Nausea and vomiting	Stool	Dark color urine	Complete blood picture	Liver Function Tests	ESR	C-reactive protein	X Ray	USG	CT	MRI	Other Imaging Studies
Amoebic liver abscess	Entamoeba histolytica	✔✔	✔			✔/✘	✔ (late stages)		✔		✔											More ill appearing than pyogenic abscess More fever than pyogenic Needle aspiration: Fluid from an ALA is odorless,reddish brown anchovy paste
Pyogenic liver abscess	Bacteria Gram-positive aerobes Gram-negative enterics Anaerobic organisms Acid fast bacilli	✔	✔	✔	✔	✔	✔✔ (acute loss)	✔	Diarrhoea	✔	Pale/dark	✔
Fungal liver abscess	Candida species	✔	✔		✔	✔	✔	✔	Diarrhoea	✔
Necrotic hepatoma	Hepatits B virus infection Hepatitis C virus infection Alcohol Oral contraceptive pills
Echinococcal (hydatid) cyst	Echinococcus granulosus
Malignancy (Hepatocellular carcinoma/Metastasis)	Hepatitis B and C Aflatoxins Alcohol Heamochromatosis Alpha 1 antitrypsin deficiency Non alcoholic fatty liver disease