Congenital syphilis screening

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2] Aravind Kuchkuntla, M.B.B.S[3]

Overview

Routine antenatal screening is recommended for syphilis.

Screening

Effective prevention and detection of congenital syphilis depends on the identification of syphilis in pregnant women and screening is a key component to decrease the incidence of congenital syphilis. The recommendations for screening are as follows:[1][2]

Screening Recommendations
Timing of Screening Test all pregnant women at the first prenatal visit.
Screening Tests
  • Nontreponemal tests commonly used for initial screening include:
    • Venereal Disease Research Laboratory (VDRL)
    • Rapid Plasma Reagin (RPR)

If screening tests are positive confirmatory tests should be done

  • Confirmatory tests include:
    • Fluorescent treponemal antibody absorbed (FTA-ABS)
    • Treponema pallidum particle agglutination (TPPA)
High Risk Population

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