Toxic shock syndrome secondary prevention
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References
Chemoprophylaxis of household contacts of STSS patients: Household contacts of people with STSS have a higher risk of invasive GAS infection compared to the general population. The Centers for Disease Control and Prevention have not made definite recommendations; some authors have recommended a 10-day course of cephalosporin
The risk of secondary cases of invasive disease is low at 2.9 per 1000. [null [82]] Several regimens have been successful in eradicating group A streptococcus from the pharynx of chronic carriers (i.e., rifampin plus intramuscular benzathine penicillin or a 10-day course of a second-generation cephalosporin or clindamycin). [null [107]] However, there are limited data concerning chemoprophylaxis for severe invasive group A streptococcal or staphylococcal infections.
American Academy of Pediatrics. Severe invasive group A streptococcal infection: a subject review. Pediatrics. 1998;101:136-140
Tanz RR, Poncher JR, Corydon KE, et al. Clindamycin treatment of chronic pharyngeal carriage of group a streptococci. J Pediatr. 1991;119:123-128