Crohn's disease risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Risk Factors
Although the cause of Crohn's disease is not known, it is believed to be an autoimmune disease that is genetically linked. The highest relative risk occurs in siblings, affecting males and females equally.
- Smokers are three times more likely to get Crohn's disease. [1]
- Living in an industrialized country
- Diets high in sweet, fatty or refined foods may also play a role.
- Certain chemicals in the diet, known as microparticles, are also hypothesized as a risk factor for the disease, as well as a poor imbalance of omega-6 to healthy omega-3 fatty acids that emerging research shows helps to improve all types of inflammatory disease.
- The most common forms of microparticles include titanium dioxide, aluminosilicates, anatase, calcium phosphate, and soil residue. These substances are ubiquitous in processed food and most toothpastes and lip glosses. Soil residue is found on fresh fruits and vegetables unless carefully removed.
- The introduction of hormonal contraception in the United States in the 1960's is linked with a dramatic increase in the incidence rate of Crohn's disease. Although a causal linkage has not been effectively shown, there remain fears that these drugs work on the digestive system in similar ways to smoking.[2]
- Gastric cancer is most often caused by the bacterium Helicobacter pylori that flourishes in cramped and unsanitary conditions.[3]
- NSAIDS
References
- ↑ Cosnes J (2004). "Tobacco and IBD: relevance in the understanding of disease mechanisms and clinical practice". Best Pract Res Clin Gastroenterol. 18 (3): 481–96. PMID 15157822.
- ↑ Lesko S, Kaufman D, Rosenberg L; et al. (1985). "Evidence for an increased risk of Crohn's disease in oral contraceptive users". Gastroenterology. 89 (5): 1046–9. PMID 4043662.
- ↑ Morris, Danielle L (2000-11-18). "Early environmental factors may have role in both Crohn's disease and gastric carcinoma - Letter to the Editor". British Medical Journal. Retrieved 2008-01-16. Unknown parameter
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