Prolactinoma history and symptoms

Prolactinoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2],Faizan Sheraz, M.D. [3]

Overview

Common symptoms of prolactinoma include headache, vision changes, decreased libido, infertility, and osteoporosis. In women, common symptoms of prolactinoma include breast tenderness, galactorrhea, and amenorrhea or oligomenorrhea.

History

• Obtaining the history is one of the most important aspects of making a diagnosis of prolactinoma. A complete history will help determine the correct therapy and helps in determining the prognosis.
• Specific areas of focus when obtaining the history are outlined below:
  • Headache.
  • Vision changes and visual field defects.
  • Delayed puberty in adolescence.
  • Decreased sexual drive.
  • Infrequent menstrual period or absent menstrual period.
  • Breast tenderness
  • Abnormal milk flow from the breast in a woman who is not pregnant or nursing.

Symptoms

Symptoms of prolactinoma can be divided as follows:

1. Symptoms due to hyperprolactinemia
2. Symptoms due to mass effect

Symptoms of Prolactinoma
Symptoms due to hyperprolactinemia			Symptoms due to mass effect
Women	Men	Both men and women	Both men and women
Amenorrhea/oligomenorrhea Galactorrhea Breast tenderness	Impotence	Infertility Decreased libido Osteoporosis	Common Symptoms: Headache Vision changes Temporal field defects (bitemporal hemianopsia) Less Common Symptoms: Cranial nerve palsies Hypothalamic impairment Hydrocephalus Hypopituitarism Cerebrospinal fluid rhinorrhea