Growth hormone deficiency MRI
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Differentiating Growth hormone deficiency from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: {MAD}}
Overview
MRI
- Brain MRI may be helpful in the diagnosis of growth hormone deficiency. Findings on MRI include:
- MRI is highly sensitive to visualize the hypothalamo-hypophyseal tract. After the clinical and biochemical diagnosis of GHD is made.[1]
- On T1-weighted imaging, a clear demarcation can be made between the adenohypophysis and the neurohypophysis, which appears as hyperintense.[2]
- This imaging is important to exclude the possibility of a pituitary tumor; it also permits diagnostic characterization by showing the presence or absence of morphological abnormalities such as anterior pituitary hypoplasia, pituitary stalk agenesis, and posterior pituitary ectopia.
- Pituitary stalk interruption syndrome (PSIS) can be diagnosed using MRI aslo.[3]
References
- ↑ Growth Hormone Research Society (2000). "Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society". J Clin Endocrinol Metab. 85 (11): 3990–3. doi:10.1210/jcem.85.11.6984. PMID 11095419.
- ↑ Dietrich RB, Lis LE, Greensite FS, Pitt D (1995). "Normal MR appearance of the pituitary gland in the first 2 years of life". AJNR Am J Neuroradiol. 16 (7): 1413–9. PMID 7484625.
- ↑ Maghnie M, Strigazzi C, Tinelli C, Autelli M, Cisternino M, Loche S; et al. (1999). "Growth hormone (GH) deficiency (GHD) of childhood onset: reassessment of GH status and evaluation of the predictive criteria for permanent GHD in young adults". J Clin Endocrinol Metab. 84 (4): 1324–8. doi:10.1210/jcem.84.4.5614. PMID 10199773.