Insulinoma historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]Amandeep Singh M.D.[3]
Overview
Pancreatic islet cells were first described by Paul Langerhans in 1869, while he was still a medical student. Insulin was first discovered by Frederick Banting and Charles Best in 1922 from a dog’s pancreas. In 1927, William J Mayo was the first to discover the association between hyperinsulinism and a functional pancreatic islet cell tumor. In 1929, Roscoe Graham was the first to perform surgical cure of an islet cell tumor.
Historical Perspective
- Pancreatic islet cells were first described by Paul Langerhans in 1869, while he was still a medical student.
- Insulin was first discovered by Frederick Banting and Charles Best in 1922 from a dog’s pancreas.
- In 1927, William J Mayo was the first to discover the association between hyperinsulinism and a functional pancreatic islet cell tumor.
- In 1929, Roscoe Graham was the first to perform surgical cure of an islet cell tumor.[1]
- Hypoglycemia was first recognized in the 19th century. In the 1920s, after the discovery of insulin and its use in the treatment of diabetics, hyperinsulinism was suspected to be a cause of hypoglycemia in non-diabetics.[2]
- A pioneering description of hyperinsulinism as a cause of hypoglycemia was published by Seale Harris in 1924.[2]
- The first report of a surgical cure of hypoglycemia by removing an islet cell tumour was in 1929.
Overview
Historical Perspective
Discovery
- In 1902, the first of adenoma of pancreatic islets was discovered by Nicholls.[3]
- In 1927 the insulinoma was first described in Mayo clinic which was dissected in 1929 in Toronto.[3]
- [Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].
- The association between hyperinsulinism and functional islet tumor was made in 1926 by Wilder-et-al after a surgery on a person who had hypoglycemia and found a n islet cell cancer with liver metastasis.[4]
- In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
- In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
Landmark Events in the Development of Treatment Strategies
- In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].
Famous Cases
- Steve Jobs, the founder and CEO of Apple Inc. had died on Oct 5,2011 because of a pancreatic neuroendocrine cancer.
- Dag Kittlaus, the creator of Siri had been diagnosed with a pancreatic neuroendocrine tumor last year.
References
- ↑ Murray PD, McKenzie DT, Swain SL, Kagnoff MF (1987). "Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression". J Immunol. 139 (8): 2669–74. PMID 3498768.
- ↑ 2.0 2.1 Insulinoma. Wikipedia. https://en.wikipedia.org/wiki/Insulinoma. Accessed on October 5,2015
- ↑ 3.0 3.1 Stamatakos M, Safioleas C, Tsaknaki S, Safioleas P, Iannescu R, Safioleas M (2009). "Insulinoma: a rare neuroendocrine pancreatic tumor". Chirurgia (Bucur). 104 (6): 669–73. PMID 20187464.
- ↑ Wilder, Russell M.; Allan, Frank N.; Power, M. H.; Robertson, H. E. (1927). "CARCINOMA OF THE ISLANDS OF THE PANCREAS". Journal of the American Medical Association. 89 (5): 348. doi:10.1001/jama.1927.02690050014007. ISSN 0002-9955.