Insulinoma historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]Amandeep Singh M.D.[3]
Overview
Historical Perspective
Discovery
- Pancreatic islet cells were first described by Paul Langerhans in 1869, while he was still a medical student.
- In 1902, the first of adenoma of pancreatic islets was discovered by Nicholls.[1]
- Insulin was first discovered by Frederick Banting and Charles Best in 1922 from a dog’s pancreas.
- In 1927, William J Mayo was the first to discover the association between hyperinsulinism and a functional pancreatic islet cell tumor.In 1927 the insulinoma was first described in Mayo clinic which was dissected in 1929 in Toronto.[1]
- The association between hyperinsulinism and functional islet tumor was made in 1926 by Wilder-et-al after a surgery on a person who had hypoglycemia and found an islet cell cancer with liver metastasis.[2]
- In 1929, the first surgical cure was performed by Roscoe Graham.[3]
- In 1935, Whipple suggested a diagnostic criteria for the diagnosis of Insulinoma called as Whipple's triad[3]
Landmark Events in the Development of Treatment Strategies
- William J Mayo, did the first operation for insulinoma in 1927 and found to be unresectable. Two years later, Roscoe Graham successfully completed the first surgical cure of an islet cell tumor.
- In 1935, Whipple's triad was developed by Virginia Kneeland Frantz and Allen O. Whipple to diagnose insulinoma.
Famous Cases
- Steve Jobs, the founder and CEO of Apple Inc. had died on Oct 5,2011 because of a pancreatic neuroendocrine cancer.
- Dag Kittlaus, the creator of Siri had been diagnosed with a pancreatic neuroendocrine tumor last year.
References
- ↑ 1.0 1.1 Stamatakos M, Safioleas C, Tsaknaki S, Safioleas P, Iannescu R, Safioleas M (2009). "Insulinoma: a rare neuroendocrine pancreatic tumor". Chirurgia (Bucur). 104 (6): 669–73. PMID 20187464.
- ↑ Wilder, Russell M.; Allan, Frank N.; Power, M. H.; Robertson, H. E. (1927). "CARCINOMA OF THE ISLANDS OF THE PANCREAS". Journal of the American Medical Association. 89 (5): 348. doi:10.1001/jama.1927.02690050014007. ISSN 0002-9955.
- ↑ 3.0 3.1 Whipple AO, Frantz VK (1935). "ADENOMA OF ISLET CELLS WITH HYPERINSULINISM: A REVIEW". Ann. Surg. 101 (6): 1299–335. PMC 1390871. PMID 17856569.