Hypoaldosteronism causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Disease name] may be caused by [cause1], [cause2], or [cause3].
OR
Common causes of [disease] include [cause1], [cause2], and [cause3].
OR
The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
OR
The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.
Causes
Life-threatening Causes
Life-threatening causes of hypoaldosteronism include:
- Adrenal infarction
- Bilateral adrenal hemorrhage(caused by trauma, anticoagulant therapy, or coagulation disorders).[1]
- Cancerous destruction of the adrenal gland, secondary to infiltrative or metastatic disease.
- Tubercular and fungal destruction of adrenal glands.
Common Causes
Common causes of Hypoaldosteronism include:[2]
- Diabetic nephropathy
- Acute glomerulonephritis
- Autoimmune/Idiopathic
- Tuberculosis
- AIDS
- CMV
- Hemorrhage
- Infarction
- Sarcoidosis
- Infections
Less common causes
Less common causes of Addison's disease include:
- Sarcoidosis
- Amyloidosis
- Fungal infections
- AIDS complications
- Hemochromatosis
- Polyglandular endocrine syndromes
- Adrenoleukodystrophy
- Adrenomyelodystrophy
- Congenital factors, including hypoplasia, familial glucocorticoid insufficiency, and enzyme defect
Drugs causing hypoaldosteronism
Other less common causes of hypoaldosteronism include drugs such as:[3][4][5][6]
| Decreased renin release | Inhibition of
aldosterone synthase |
Decreased production
of aldosterone |
Decreased effect of
aldosterone |
Drugs that impair
adrenal function |
Direct inhibition
of zona glomerulosa |
Dopaminergic agonists |
|---|---|---|---|---|---|---|
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Less common causes of disease name include:
- [cause1]
- [cause2]
- [cause3]
Genetic Causes
- [Disease name] is caused by a mutation in the [gene name] gene.
Causes in Alphabetical Order
List the causes of the disease in alphabetical order.
References
- ↑ LaBan MM, Whitmore CE, Taylor RS (2003). "Bilateral adrenal hemorrhage after anticoagulation prophylaxis for bilateral knee arthroplasty". Am J Phys Med Rehabil. 82 (5): 418–20. doi:10.1097/01.PHM.0000064741.97586.E4. PMID 12704285.
- ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:14-15
- ↑ Missale C, Lombardi C, De Cotiis R, Memo M, Carruba MO, Spano PF (1989). "Dopaminergic receptor mechanisms modulating the renin-angiotensin system and aldosterone secretion: an overview". J. Cardiovasc. Pharmacol. 14 Suppl 8: S29–39. PMID 2483440.
- ↑ Akizuki O, Inayoshi A, Kitayama T, Yao K, Shirakura S, Sasaki K, Kusaka H, Matsubara M (2008). "Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R". Eur. J. Pharmacol. 584 (2–3): 424–34. doi:10.1016/j.ejphar.2008.02.001. PMID 18331727.
- ↑ Ikeda, Keiichi; Isaka, Tsuyoshi; Fujioka, Kouki; Manome, Yoshinobu; Tojo, Katsuyoshi (2012). "Suppression of Aldosterone Synthesis and Secretion by Channel Antagonists". International Journal of Endocrinology. 2012: 1–6. doi:10.1155/2012/519467. ISSN 1687-8337.
- ↑ McKenna TJ, Island DP, Nicholson WE, Liddle GW (1978). "The effects of potassium on early and late steps in aldosterone biosynthesis in cells of the zona glomerulosa". Endocrinology. 103 (4): 1411–6. doi:10.1210/endo-103-4-1411. PMID 744152.