Osteoarthritis causes
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Osteoarthritis Microchapters |
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Osteoarthritis causes On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Robert G. Badgett, M.D. [2] Luke Rusowicz-Orazem, B.S.
Overview
Causes
Osteoarthritis often affects multiple members of the same family, suggesting that there is hereditary susceptibility to this condition. A number of studies have shown that there is a greater prevalence of the disease between siblings and especially identical twins, indicating a hereditary basis. Up to 60% of OA cases are thought to result from genetic factors. Researchers are also investigating the possibility of allergies, infections, or fungi as a cause. There is some evidence that allergies, whether fungal, infectious or systemically induced, may be a significant contributing factor to the appearance of osteoarthritis in a synovial sac. Randomized, controlled studies have shown a 40% reduction in joint degeneration if Tetracycline derivative antibiotics are taken consistently over time.
Obesity may contribute to osteoarthritis of the knee.[1][2][3]
Leg-length inequality > 1 cm is associated with osteoarthritis of the knee.[4]
Common Causes
- Aseptic necrosis of bone
- Asymmetric leg length
- Avascular necrosis
- Chondrocalcinosis 1
- Chondrocalcinosis 2
- Developmental dysplasia of the hip
- Ehlers-danlos syndrome
- Familial chondrocalcinosis
- Fracture of bone
- Joint injury
- Meniscectomy
- Multiple epiphyseal dysplasia
- Muscle dysfunction
- Osteochondritis dissecans
- Syringomyelia
- Tabes dorsalis
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ Nguyen US, Zhang Y, Zhu Y, Niu J, Zhang B, Felson DT (2011). "Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data". Ann Intern Med. 155 (11): 725–32. doi:10.1059/0003-4819-155-11-201112060-00004. PMC 3408027. PMID 22147711.
- ↑ McAlindon TE, Wilson PW, Aliabadi P, Weissman B, Felson DT (1999). "Level of physical activity and the risk of radiographic and symptomatic knee osteoarthritis in the elderly: the Framingham study". Am J Med. 106 (2): 151–7. PMID 10230743.
- ↑ Hart DJ, Doyle DV, Spector TD (1999). "Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study". Arthritis Rheum. 42 (1): 17–24. doi:10.1002/1529-0131(199901)42:1<17::AID-ANR2>3.0.CO;2-E. PMID 9920009.
- ↑ Harvey WF, Yang M, Cooke TD, Segal NA, Lane N, Lewis CE; et al. (2010). "Association of leg-length inequality with knee osteoarthritis: a cohort study". Ann Intern Med. 152 (5): 287–95. doi:10.1059/0003-4819-152-5-201003020-00006. PMID 20194234.