Delayed puberty classification

Delayed puberty Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

Overview

Delayed puberty is almost always due to physiologic exaggerated prolongation of puberty timing in boys, a condition called "constitutional delay of growth and puberty (CDGP)". But the disease may sometimes has another pathophysiologies, such as hypergonadotropic hypogonadism, permanent hypogonadotropic hypogonadism, and functional hypogonadotropic hypogonadism.

Classification

Delayed puberty is almost always due to physiologic exaggerated prolongation of puberty timing in boys, a condition called "constitutional delay of growth and puberty (CDGP)". Delayed puberty may sometimes has another pathophysiologies, however, the CDGP is the most common cause of delayed puberty in both boys and girls. The main classification of delayed puberty is as following:

Delayed puberty classification

LH, FSH, and GnRH measurement

Normal

Abnormal

Constitutional delay of growth and puberty (CDGP)

LH and FSH increased GnRH increased

LH and FSH decreased GnRH decreased

LH and FSH decreased GnRH decreased (transient)

Hypergonadotropic hypogonadism (primary hypogonadism)

Permanent hypogonadotropic hypogonadism (secondary hypogonadism)

Transient hypogonadotropic hypogonadism (functional hypogonadism)