Delayed puberty laboratory findings
Delayed puberty Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Delayed puberty laboratory findings On the Web |
American Roentgen Ray Society Images of Delayed puberty laboratory findings |
Risk calculators and risk factors for Delayed puberty laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
OR
[Test] is usually normal among patients with [disease name].
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
There are no diagnostic laboratory findings associated with [disease name].
Laboratory Findings
The most valuable blood tests are the gonadotropins, because elevation confirms immediately a defect of the gonads or deficiency of the sex steroids. In many instances, screening tests such as a complete blood count, general chemistry screens, thyroid tests, and urinalysis may be worthwhile.
- There are no diagnostic laboratory findings associated with [disease name].
OR
- An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
- [Test] is usually normal among patients with [disease name].
- Laboratory findings consistent with the diagnosis of [disease name] include
- [Abnormal test 1]
- [Abnormal test 2]
- [Abnormal test 3]
- Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
Delayed puberty | |||||||||||||||||||||||||||||||||||||||||||||||
Clinical suspicion to delayed puberty (Absent growth spurt along with lack of testicular enlargement or breast development) | |||||||||||||||||||||||||||||||||||||||||||||||
First line evaluation • Biochemical analyses • Bone age radiography • Basal serum LH, FSH, IGF-1, TSH, free thyroxine, and testosterone (in boys) | |||||||||||||||||||||||||||||||||||||||||||||||
Reduced or normal LH and FSH | Elevated FSH or LH | ||||||||||||||||||||||||||||||||||||||||||||||
Growth rate as prepubertal | Growth rate lower than prepubertal | ||||||||||||||||||||||||||||||||||||||||||||||
Constitutional delay of growth and puberty (CDGP) | Gonadotropin releasing hormone (GnRH) deficiency | Transient hypogonadotropic hypogonadism | Permanent hypogonadotropic hypogonadism | Hypergonadotropic hypogonadism | |||||||||||||||||||||||||||||||||||||||||||
Second line evaluation | Second line evaluation | Second line evaluation | |||||||||||||||||||||||||||||||||||||||||||||
• GnRH test • hCG stimulation test • Serum inhibin B • Olfactory-function test • Genetic testing • MRI | Evaluating more underlying diseases: • MRI • Prolactin | Evaluating more underlying diseases: • Karyotype • Serum inhibin B | |||||||||||||||||||||||||||||||||||||||||||||
Low BMI | Normal BMI | High BMI | |||||||||||||||||||||||||||||||||||||||||||||
• GI disorder • Malnutrition • Anorexia | • Hypothyreosis • Hyperprolactinemia • Multiple pituitary hormone deficiency | • Glucocorticoid excess (iatrogenic, Cushing’s disease) • Hypothyroidism | |||||||||||||||||||||||||||||||||||||||||||||
Follow up Evaluate the need for the induction of secondary sex characteristics | Treat underlying disease | Treat with sex steroids | |||||||||||||||||||||||||||||||||||||||||||||