Autoimmune hepatitis classification
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Autoimmune hepatitis Microchapters |
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Autoimmune hepatitis classification On the Web |
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American Roentgen Ray Society Images of Autoimmune hepatitis classification |
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Risk calculators and risk factors for Autoimmune hepatitis classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ;Manpreet Kaur, MD [2]
Overview
Classification
According to European Association for the Study of the Liver, there are three types of Autoimmune hepatitis discussed below:
- Autoimmune hepatitis Type-1:
- Common type of AIH (accounts almost for 90% of AIH cases)
- Presents at any age
- Antibodies like ANA, SMA or anti-SLA/LP can be detected
- Association with HLA DR3, DR4, and DR13
- Treatment failure is rare but relapse occur after withdrawl of treatment and long term maintenance therapy is advised
- Autoimmune hepatitis Type 2:
- Accounts for 10% of AIH cases
- Presents usually in childhood and young adulthood
- Antibodies like anti-LKM1, anti-LC1 and rarely anti-LKM3 can be detected
- Association with HLA DR3 and DR7 frequent failure of treatment and frequent relapse rates after drug withdrawal; the need for long-term maintenance therapy very common • AIH-3: SLA/LP positive, otherwise very similar to AIH-1; often Ro52-antibody positive. Possibly more severe