PDE7A

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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A is an enzyme that in humans is encoded by the PDE7A gene.^[1]^[2]^[3] Mammals possess 21 cyclic nucleotide phosphodiesterase (PDE) genes that are pharmacologically grouped into 11 families. PDE7A is one of two genes in the PDE7 family, the other being PDE7B. The PDE7 family, along with the PDE4 and PDE8 families, are are cAMP-specific, showing little to no activity against 3', 5'-cyclic guanosine monophosphate (cGMP).

References

↑ Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M (Jul 1993). "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae". J Biol Chem. 268 (17): 12925–32. PMID 8389765.
↑ Han P, Fletcher CF, Copeland NG, Jenkins NA, Yaremko LM, Michaeli T (Jun 1998). "Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13". Genomics. 48 (2): 275–6. doi:10.1006/geno.1997.5168. PMID 9521885.
↑ "Entrez Gene: PDE7A phosphodiesterase 7A".

Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somat. Cell Mol. Genet. 20 (2): 75–86. doi:10.1007/BF02290677. PMID 8009369.
Han P, Zhu X, Michaeli T (1997). "Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart". J. Biol. Chem. 272 (26): 16152–7. doi:10.1074/jbc.272.26.16152. PMID 9195912.
Zhou L, Thompson WJ, Potter DE (1999). "Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells". Invest. Ophthalmol. Vis. Sci. 40 (8): 1745–52. PMID 10393044.
Miró X, Casacuberta JM, Gutiérrez-López MD, de Landázuri MO, Puigdomènech P (2000). "Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha(1)". Biochem. Biophys. Res. Commun. 274 (2): 415–21. doi:10.1006/bbrc.2000.3146. PMID 10913353.
Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
Glavas NA, Ostenson C, Schaefer JB, Vasta V, Beavo JA (2001). "T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6319–24. Bibcode:2001PNAS...98.6319G. doi:10.1073/pnas.101131098. PMC 33466. PMID 11371644.
Lee R, Wolda S, Moon E, Esselstyn J, Hertel C, Lerner A (2002). "PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP". Cell. Signal. 14 (3): 277–84. doi:10.1016/S0898-6568(01)00250-9. PMID 11812656.
Nakata A, Ogawa K, Sasaki T, Koyama N, Wada K, Kotera J, Kikkawa H, Omori K, Kaminuma O (2002). "Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors". Clin. Exp. Immunol. 128 (3): 460–6. doi:10.1046/j.1365-2249.2002.01856.x. PMC 1906253. PMID 12067300.
Smith SJ, Brookes-Fazakerley S, Donnelly LE, Barnes PJ, Barnette MS, Giembycz MA (2003). "Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (2): L279–89. doi:10.1152/ajplung.00170.2002. PMID 12388353.
Torras-Llort M, Azorín F (2003). "Functional characterization of the human phosphodiesterase 7A1 promoter". Biochem. J. 373 (Pt 3): 835–43. doi:10.1042/BJ20021829. PMC 1223549. PMID 12737631.
Wang H, Liu Y, Chen Y, Robinson H, Ke H (2005). "Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7". J. Biol. Chem. 280 (35): 30949–55. doi:10.1074/jbc.M504398200. PMID 15994308.
Sánchez AI, Meneses R, Mínguez JM, Núñez A, Castillo RR, Filace F, Burgos C, Vaquero JJ, Álvarez-Builla J, Cortés-Cabrera A, Gago F, Terricabras E, Segarra V (2014). "Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold". Org. Biomol. Chem. 12 (24): 4233–42. doi:10.1039/c4ob00175c. PMID 24838636.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[pmid8389765-1] Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M (Jul 1993). "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae". J Biol Chem. 268 (17): 12925–32. PMID 8389765.

[pmid9521885-2] Han P, Fletcher CF, Copeland NG, Jenkins NA, Yaremko LM, Michaeli T (Jun 1998). "Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13". Genomics. 48 (2): 275–6. doi:10.1006/geno.1997.5168. PMID 9521885.

[entrez-3] "Entrez Gene: PDE7A phosphodiesterase 7A".

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[2]

[3]

PDE7A

References

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