Sinusoidal obstruction syndrome history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
History and Symptoms
History
Patients with sinusoidal obstruction syndrome may have a positive history of:[1][2][3]
- Hematopoietic cell transplantation (HCT)
- Preexisting liver disease
- Chemotherapeutic agents in non-transplant settings
- Liver transplantation
- High dose radiation therapy
Common Symptoms
Common symptoms of sinusoidal obstruction syndrome include:
- Tender hepatomegaly
- Weight gain
- Ascites
- Abdominal pain or distention
- Jaundice
- Nausea and vomiting
- Anorexia
References
- ↑ McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA (1993). "Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients". Ann. Intern. Med. 118 (4): 255–67. PMID 8420443.
- ↑ Bearman SI (1995). "The syndrome of hepatic veno-occlusive disease after marrow transplantation". Blood. 85 (11): 3005–20. PMID 7756636.
- ↑ Richardson P, Guinan E (1999). "The pathology, diagnosis, and treatment of hepatic veno-occlusive disease: current status and novel approaches". Br. J. Haematol. 107 (3): 485–93. PMID 10583247.