Idiopathic pulmonary fibrosis causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Causes
Common causes of pulmonary fibrosis include autoimmunity, rheumatoid arthritis, scleroderma, tuberculosis, SLE, sarocoidosis, and polymyoisitis. Other causes of pulmonary fibrosis include environmental factors as cigarette smoking and dust exposure.
Common Causes
The most common causes of pulmonary fibrosis are:
- Autoimmune diseases:
- Rheumatoid arthritis
- Scleroderma (systemic sclerosis)
- Tuberculosis
- Pneumonia
- Systemic lupus erythematosus
- Sarcoidosis
- Polymyositis
- Dermatomyositis
- Anti-synthetase syndrome
- GERD - Gastroesophageal Reflux Disease
Environmental Factors
- Cigarette smoke
- Asbestos exposure
- Silica exposure
- Coal dust exposure
- Beryllium exposure
- Hard metal dusts exposure
- Animal protein exposure
- Bacteria, mold exposure
- Radiation
Drugs
- lomustine
- panitumumab
- penicillamine
- rifapentin
- methotrexate (Trexall)
- cyclophosphamide (Cytoxan)
- amiodarone (Cordarone
- Nexterone, (Pacerone)
- propranolol (Inderol, Innopran)
- nitrofurantoin (Macrobid, Macrodantin)
- sulfasalazine (Azulfidine)
Genetic and Inherited Diseases also make up 10-15% of idiopathic pulmonary fibrosis diagnosis'.
Causes by Organ System
Cardiovascular | No underlying causes |
Chemical / poisoning | No underlying causes |
Dermatologic | No underlying causes |
Drug Side Effect | methotrexate, Trexall, cyclophosphamide, Cytoxan, amiodarone, Cordarone, Nexterone, Pacerone, propranolol, Inderol, Innopran, nitrofurantoin, Macrobid, Macrodantin, sulfasalazine, Azulfidine |
Ear Nose Throat | No underlying causes |
Endocrine | No underlying causes |
Environmental | Cigarette Smoke, Asbestos, silica, coal dust, beryllium, hard metal dusts, animal proteins, bacteria, molds, Radiation |
Gastroenterologic | Gastroesophageal reflux disease |
Genetic | No underlying causes |
Hematologic | No underlying causes |
Iatrogenic | No underlying causes |
Infectious Disease | Dermatomyositis, Polymyositis |
Musculoskeletal / Ortho | Rheumatoid arthritis |
Neurologic | No underlying causes |
Nutritional / Metabolic | No underlying causes |
Obstetric/Gynecologic | No underlying causes |
Oncologic | No underlying causes |
Opthalmologic | No underlying causes |
Overdose / Toxicity | No underlying causes |
Psychiatric | No underlying causes |
Pulmonary | Tuberculosis, Pneumonia, Anti-synthetase syndrome |
Renal / Electrolyte | No underlying causes |
Rheum / Immune / Allergy | Sarcoidosis, systemic lupus erythematosus, rheumatoid arthritis, lupus pleuritis |
Sexual | No underlying causes |
Trauma | No underlying causes |
Urologic | No underlying causes |
Dental | No underlying causes |
Miscellaneous | No underlying causes |
Causes in Alphabetical Order
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