Mixed connective tissue disease historical perspective

Mixed connective tissue disease Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

Historical Perspective

• MCTD was first defined by Sharp et al., in 1972.
• MCTD has been the first rheumatic disease syndrome defined by a serologic test (positive U1RNP).