Mixed connective tissue disease diagnostic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

Overview

The diagnosis of MCTD is made when both of the following diagnostic criteria are met:^[1]
- Overlapping clinical features between two or more systemic autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, dermatomyositis, polymyositis, and scleroderma)
- Presence of antibodies against the U1 small nuclear ribonucleoprotein autoantigen (U1snRNP)

↑ Tani C, Carli L, Vagnani S, Talarico R, Baldini C, Mosca M, Bombardieri S (2014). "The diagnosis and classification of mixed connective tissue disease". J. Autoimmun. 48-49: 46–9. doi:10.1016/j.jaut.2014.01.008. PMID 24461387.