Buerger's disease pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]
Overview
Buerger's disease or thromboangiitis obliterans is a segmental vascular disease that causes occlusion and inflammation of the small and medium-sized vessels. Buerger's disease vasculitis is unique in having features of hypercellularity with intraluminal thrombi in the vessel wall, but sparing the elastic internal laminae of the vessel wall. The details of pathogenesis is still largely unknown.
Pathophysiology
Buerger's disease or thromboangiitis obliterans is a segmental vascular disease that causes occlusion and inflammation of the small and medium-sized vessels. Buerger's disease vasculitis is unique in having hypercellularity with intraluminal thrombi within the vessel wall that spares the elastic internal laminae of the vessel wall. The details of pathogenesis is still largely unknown.
- In the acute phase the following occurs:
- The external lamina of the vessels of the distal extremities are usually affected first by inflammatory thrombi.
- The thrombi cause vessel occlusion whilst leukocytes and giant cells infiltrate the vessel margins.
- Fibrinoid necrosis is not a feature of Buerger's disease, however, microabscesses may also be present.
- Superficial veins in particular may show evidence of thrombophlebitis and this is characteristic and diagnostic of the acute phase.
- The subacute or intermediate phase is characterized by progressive organization of thrombi with the vessel.
- The chronic phase is characterized by the continued presence of organized thrombi with fibrosis, ending with the resolution of inflammation.
- In the chronic phase, the diseased vessels are not distinct from other vascular diseases.
Genetics
- The development of Buerger's disease may be the result of an immunologic phenomenon that leads to vascular dysfunction and the development of inflammatory thrombi.
- Patients with Buerger's disease have been identified to have a hypersensitivity against tobacco extracts that are injected intradermally.
- Evidence has demonstrated that upon exposure to tobacco there is an increased cellular response against collagen type I and III with increased levels of circulating anti-endothelial cell antibody.
- This increased cellular sensitivity leads to an impaired relaxation mechanism of the peripheral vessels.
- Cytokines are also thought to be produced in large quantities and may lead to the activation of inflammatory signals.
- Genes that have been identified to be associated with tobacco hypersensitivity in patients with Buerger's disease include HLA-A9, HLA-A54, and HLA-B5.
Smoking
- Smoking tobacco is critical to the initiation, progression and recurrence of Buerger's disease.
- It is not understood how smoking leads to the development of thromboangiitis, however, it has been hypothesized that chemical compounds within the tobacco smoke leads to a delayed hypersensitivity and may directly cause a toxic angiitis.
Gross Pathology
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Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Prothrombotic factors may also play a role in the pathogenesis of thromboangiitis obliterans. The presence of anticardiolipin antibodies is associated with an increased risk and severity of disease [43,44].