Vitamin B12 deficiency historical perspective

	Vitamin B12 deficiency Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Vitamin B 12 deficiency may be caused by:

Decrease intrinsic factor due autoimmune destruction of parietal cell
Decrease Gastric acid production due to proton pump inhibitor and histamine 2 receptor antagonists
Gastric by pass surgery because intrinsic factor is produce by parietal cell of stomach
Tapeworm (Diphyllobothrium latum ) ingested from contaminated fish , tapeworm saps nutrients
Crohn's disease

References