Hyponatremia differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Saeedeh Kowsarnia M.D.[2] Iqra Qamar M.D.[3]
Overview
Hyponatremia must be differentiated from other diseases that cause
Differentiating Hyponatremia from other Diseases
Classification by volume status | Disease | Clinical manifestations | Paraclinical Findings | Comments | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hypervolemic | Symptoms and Signs | Lab Findings | Imaging | |||||||||||||||||||
Muscle weakness/ Cramps | Thirst | Vomiting/ Diarrhea | Confusion/ Dizziness | Seizures | JVP | Edema | Crackles | Ascites | Tachycardia | Hypotension | Oliguria | CBC | Urine Analysis | Serum Osmolality | ADH levels | Other | ||||||
Urine Na | Urine Osm | FeNa | ||||||||||||||||||||
Renal failure | >20 | - | >1% | |||||||||||||||||||
Congestive heart failure | <10 | - | <1% | |||||||||||||||||||
Cirrhosis | <10 | - | <1% | |||||||||||||||||||
Euvolemic | SIADH | - | >100 | - | ||||||||||||||||||
Hypothyroidism | - | >100 | - | |||||||||||||||||||
Adrenal insufficiency | - | >100 | - | |||||||||||||||||||
Psychogenic polydipsia | - | <100 | - | |||||||||||||||||||
Pregnancy | - | Variable | - | |||||||||||||||||||
Anorexia (Chronic malnutrition) | - | Variable | - | |||||||||||||||||||
Hypovolemic | Diuretic induced hyponatremia | >20 | - | >1% | ||||||||||||||||||
Non oliguric ATN | >20 | - | >1% | |||||||||||||||||||
Diseases causing 3rd spacing (Pancreatitis, SBO) | <10 | - | <1% | |||||||||||||||||||
Gastroenteritis | <10 | - | <1% | |||||||||||||||||||
Sweating | <10 | - | <1% |