Behçet's disease natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]

Overview

The symptoms of Behcet disease usually develop in the second to third decade of life, and start with symptoms such as uveitis, mouth sores, and skin lesions. Common complications of Behcet disease include neuro Behcet, vision loss, and aneurysm. Depending on the extent of the disease at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good. The worst prognoses are associated with retinal vasculitis, leading to blindness; vascular aneurysm formation, with possible rupture; and neuro–Behçet syndrome, which may lead to dementia despite appropriate aggressive treatment.

Natural History, Complications, and Prognosis

Natural History

• The symptoms of Behcet disease usually develop in the second to third decade of life, and start with symptoms such as uveitis, mouth sores, and skin lesions.

Complications

• Common complications of Behcet disease include:
  • Neuro Behcet
  • Vision loss
  • Aneurysm

Prognosis

• Depending on the extent of the disease at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.
• The worst prognoses are associated with retinal vasculitis, leading to blindness; vascular aneurysm formation, with possible rupture; and neuro–Behçet syndrome, which may lead to dementia despite appropriate aggressive treatment.