Methemoglobinemia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Template:Aksiniya K. Stevasarova, M.D.
Overview
Congenital (Hereditary) Methemoglobinemia
There are three main congenital conditions that lead to methemoglobinemia:
1. Cytochrome b5 reductase deficiency and pyruvate kinase deficiency
3. Presence of abnormal hemoglobin (Hb M)
Acquired or Acute Methemoglobinemia
Most common cause include different oxidant drugs, toxins or chemicals
History and Symptoms
Depending on the levels of MetHb in the blood we can observe different symptoms as follows: MetHb 15 % presents with skin and blood color changes at levels, Levels above 15 % will result in hypoxia and levels above 70% can lead to death.
Cyanosis that is unresponsive to oxygen treatment is the main physical finding in people with methemoglobinemia, along with that the patient can present with dizziness, nausea and shortness of breath.