Glomerular disease

	Glomerular disease Main page
Glomerular disease patient information
Overview
Classification 1- Poststreptococcal Glomerulonephritis 2- Renal disease due to Subacute Bacterial Endocarditis, or cardiac shunt 3- Lupus nephritis 4- Goodpasture syndrome 5- IgA nephropathy 6- Granulomatosis with Polyangiitis (Wegener's) 7- Microscopic Polyangiitis 8- Churg-Strauss Syndrome 9- Membranoproliferative Glomerulonephritis 10- Henoch-Schönlein purpura 11- Cryoglobulinemia 12- Minimal change disease 13- Focal segmental glomerulosclerosis 14- Membranous glomerulonephritis 15- Diabetic Nephropathy 16- Glomerular deposition disease 17- Alport's Syndrome 18- Thin Basement Membrane Disease 19- Nail-Patella Syndrome 20- Hypertensive nephrosclerosis 21- Cholesterol Emboli 22- Sickle Cell Disease 23- Thrombotic Microangiopathies 24- Antiphospholipid Antibody Syndrome
Pathophysiology
Differential Diagnosis
Diagnosis
Prevention

	Glomerular disease;
	Acute Glomerulonephritis: Micro H&E high mag; an excellent example of acute exudative glomerulonephritis. ; Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

This page contains general information about Glomerular disease. For more information on specific types, please visit the pages on nephritic syndrome, nephrotic syndrome, Fabry's disease, amyloidosis, pulmonary-renal syndromes (vasculitis), thin basement membrane disease, Alport's Syndrome, anti-GBM Disease, hypertensive nephrosclerosis, and subacute bacterial endocarditis.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mehrian Jafarizade, M.D [2], Syed Hassan A. Kazmi BSc, MD [3]

Overview

Glomerular disease is a condition that affects the glomerulus. It consists of different diseases with different clinical courses and treatment options. Glomerular disease can be isolated hematuria, isolated proteinuria; acute or chronic glomerulonephritis, and nephrotic or nephritic features of glomerulonephritis. The end stage of all of these diseases will be glomerulosclerosi swhich is characterized by fibrosis of the glomerulus, and end-stage renal disease.

Classification

Glomerular dieseases can be classified into several clinical and pathological syndromes as below:

Syndrome	Disease
Acute nephritic syndromes	Poststreptococcal glomerulonephritis Subacute bacterial endocarditis Lupus nephritis Antiglomerular basement membrane disease IgA nephropathy ANCA Small-Vessel Vasculitis Granulomatosis with Polyangiitis (Wegener's) Microscopic Polyangiitis Churg-Strauss Syndrome Membranoproliferative Glomerulonephritis Mesangioproliferative Glomerulonephritis
Nephrotic syndrome	Minimal Change Disease Focal Segmental Glomerulosclerosis Membranous Glomerulonephritis Diabetic Nephropathy
Glomerular Deposition Diseases	Light Chain Deposition Disease Renal Amyloidosis Fibrillary-Immunotactoid Glomerulopathy Fabry's Disease
Pulmonary-Renal Syndromes:	Goodpasture's syndrome Granulomatosis with polyangiitis (Wegener's) Microscopic polyangiitis Churg-Strauss vasculitis Henoch-Schönlein purpura Cryoglobulinemia
Basement Membrane Syndromes	Anti-GBM Disease Alport's Syndrome Thin Basement Membrane Disease Nail-Patella Syndrome
Glomerular-Vascular Syndromes	Atherosclerotic Nephropathy Hypertensive nephrosclerosis Cholesterol Emboli Sickle Cell Disease Thrombotic Microangiopathies Antiphospholipid Antibody Syndrome
Infectious Disease–Associated Syndromes	Post-Streptococcal Glomerulonephritis Subacute bacterial endocarditis Human Immunodeficiency Virus Hepatitis B and C Other Viruses Syphilis Leprosy Malaria Schistosomiasis Other Parasites

Also, glomerular diseases can be classified based on their clinical and urinary pattern in to below types:

Mild nephritc:

This category include mild nephritic sediment that is associated with less than half involvement of glomeruli.

Severe nephritic:

More severe clinical features such as edema, heavy proteinuria, hypertension, and/or renal failure may occur.

Nephrotic:

This syndrome is associated with heavy proteinuria and lipiduria.