Focal segmental glomerulosclerosis causes
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Focal segmental glomerulosclerosis Microchapters |
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Differentiating Focal segmental glomerulosclerosis from other Diseases |
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Diagnosis |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Causes
Familial
- Mutations in alpha actinin 4
- Mutations in NPHS1 (nephrin)
- Mutations in NPHS2 (podocin)
- Mutations in WT-1
- Mutations in TRPC6
- Mutations in SCARB2 (LIMP2)
- Mutations in INF2 (formin)
- Mutations in CD2-associated protein
- Mitochondrial cytopathies
Virus Associated
Medication
- Heroin
- Interferon alpha
- Lithium
- Pamidronate/aledronate
- Anabolic steroids
Adaptive Structural-Functional Responses
Reduced Kidney Size
- Oligomeganephronia
- Unilateral kidney agenesis
- Kidney dysplasia
- Cortical necrosis
- Reflux nephropathy
- Surgical kidney ablation
- Chronic allograft nephropathy
- Any advanced kidney disease with reduction in functioning nephrons
Initially Normal Kidney Mass
Malignancy
Nonspecific Pattern of FSGS Caused by Kidney Scarring in Glomerular Disease
- Focal proliferative glomerulonephritis
- IgA nephropathy
- Lupus nephritis
- Pauci-immune focal necrotizing and crescentic glomerulonephritis
- Alport's syndrome (hereditary nephritis)
- Membranous nephropathy
- Thrombotic microangiopathy