Focal segmental glomerulosclerosis natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]
Overview
Several clinical and pathological factors are associated with poor renal outcome. The most important prognostic factor in FSGS is the patient's response to therapy. Proteinuria is an important predictor of spontaneous remission or progression of FSGS into ESRD. Generally, spontaneous remission is an unlikely event in FSGS; and more than 50% of patients with nephrotic-range proteinuria reach ESRD within 3-8 years. Other important prognostic factors include male gender, black race, high level of serum creatinine and collapsing variant on histopathological analysis.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of focal segmental glomerulosclerosis usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
- The symptoms of (disease name) typically develop ___ years after exposure to ___.
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
Common complications of focal segmental glomerulosclerosis include:[1]
- End stage renal disease
- Malnutrition
- Infections
- Nephrotic syndrome
Prognosis
- There are several clinical and pathological features which predict the outcome.
- Factors which are associated with worse prognosis of focal segmental glomerulosclerosis include:[2][3]:
- Black race
- Increased degrees of proteinuria
- renal insufficiency
- Increased severity of interstitial fibrosis
- Tubular atrophy in biopsy specimens
References
- ↑ Korbet SM (1999). "Clinical picture and outcome of primary focal segmental glomerulosclerosis". Nephrol Dial Transplant. 14 Suppl 3: 68–73. PMID 10382985.
- ↑ "Focal Segmental Glomerulosclerosis in Nephrotic Adults: Presentation, Prognosis, and Response to Therapy of the Histologic Variants".
- ↑ Sohal, DS; Prabhakar, SS (November 02, 2011). "Focal segmental glomerulosclerosis" (PDF). Interchopen. InTech. Retrieved 3 December 2013. Check date values in:
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