Leiomyosarcoma natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Natural History

• The majority of patients with leiomyosarcoma remain asymptomatic for decades.
• Most leiomyosarcomas are diagnosed incidentally at an advanced stage.

Complications

They are invariably aggressive and associated with the poor prognosis.

Prognosis

The prognosis of leiomyosarcoma is poor and it depends on varying factors:

• Tumor size
• Tumor location
• Tumor type/Grade
• DNA content
• Hormonal receptor status
• cellular division and mitotic rate
• local and distant extension
• Whether or not the tumor can be removed by surgery
• The patient’s general health

Survival Rate of Leiomyosarcoma by staging:

Stage	Percentage
stage 1	60
stage 2	35
stage 3	28
stage 4	15

References

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