Leiomyosarcoma natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor.Overall survival rate ranges from 15% to 25% with a median survival of only 10 months.

Natural History

Most Leiomyosarcoma are diagnosed incidentally at an advanced stage. A leiomyosarcoma, especially in the early stages, may not be associated with any obvious symptoms (asymptomatic).The majority of patients with leiomyosarcoma remain asymptomatic for decades. General symptoms associated with cancer may occur including fatigue, fever, weight loss, a general feeling of ill health (malaise), and nausea and vomiting.

Complications

They are invariably aggressive that may metastasize to other areas of the body such as the lungs or liver, potentially causing life-threatening complications. Leiomyosarcoma has a high risk of recurring of about 53% to 71% after treatment, if not diagnosed early.

Prognosis

The prognosis of leiomyosarcoma is poor and it depends on varying factors:"Leiomyosarcoma - Survival Rate, Symptoms, Prognosis, Treatment - CancerWall.com - Cancers & Tumors Information, Research & More".

• Tumor size
• Tumor location
• Tumor type/Grade
• DNA content
• Hormonal receptor status
• cellular division and mitotic rate
• local and distant extension
• Whether or not the tumor can be removed by surgery
• The patient’s general health

Survival Rate of Leiomyosarcoma by staging:

Stage	Percentage
stage 1	60
stage 2	35
stage 3	28
stage 4	15

References

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