Kidney stone natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

OR

Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].

OR

Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

If left untreated, <30% of patients with nephrolithiasis may progress to develop renal colicky pain due to increase in rate of growth.^[1]
Most of the stones pass spontaneously. about 10-20% of symptom causing stones fail to pass.^[2]
Less than 30% caused renal colic, less than 20% were operated on for pain and 7% spontaneously passed. Lower poles stones were significantly less likely to cause symptoms or pass spontaneously. Despite 3 stones causing silent hydronephrosissuggestive of obstruction, regular followup imaging facilitated interventions t

Prognosis is generally excellent.
Approximately 80-85% resolve spontaneously
Recurrence rates for calcium stones after the initial event is 40–50% at the end of 5 years and 50–60% at the end of 10 years.^[6]

↑ Dropkin BM, Moses RA, Sharma D, Pais VM (April 2015). "The natural history of nonobstructing asymptomatic renal stones managed with active surveillance". J. Urol. 193 (4): 1265–9. doi:10.1016/j.juro.2014.11.056. PMID 25463995.
↑ Worcester EM, Coe FL (June 2008). "Nephrolithiasis". Prim. Care. 35 (2): 369–91, vii. doi:10.1016/j.pop.2008.01.005. PMC 2518455. PMID 18486720.
↑ Madore F, Stampfer MJ, Willett WC, Speizer FE, Curhan GC (November 1998). "Nephrolithiasis and risk of hypertension in women". Am. J. Kidney Dis. 32 (5): 802–7. PMID 9820450.
↑ Ferraro PM, Taylor EN, Eisner BH, Gambaro G, Rimm EB, Mukamal KJ, Curhan GC (July 2013). "History of kidney stones and the risk of coronary heart disease". JAMA. 310 (4): 408–15. doi:10.1001/jama.2013.8780. PMC 4019927. PMID 23917291.
↑ Denburg MR, Leonard MB, Haynes K, Tuchman S, Tasian G, Shults J, Copelovitch L (December 2014). "Risk of fracture in urolithiasis: a population-based cohort study using the health improvement network". Clin J Am Soc Nephrol. 9 (12): 2133–40. doi:10.2215/CJN.04340514. PMC 4255404. PMID 25341724.
↑ Worcester EM, Coe FL (June 2008). "Nephrolithiasis". Prim. Care. 35 (2): 369–91, vii. doi:10.1016/j.pop.2008.01.005. PMC 2518455. PMID 18486720.