Membranoproliferative glomerulonephritis epidemiology and demographics
Overview
Since Membranoproliferative Glomerulonephritis (MPGN) is a small portion of all glomerular disease, there is not enough evidence to completely demonstrate the epidemiology of this specific category.
Albeit, there are strong valid studies demonstrate the incidence and prevalence of all glomerular diseases.
Correlation of age and sex with glomerular disease
Due to the pathophysiology of glomerular disease, incidence of most of the glomerular disease is in children and young adult, with no sex predilection .[1][2][3]
| Age-adjusted trends in patient demographics among patients with specified glomerular disease diagnoses* | |||||
|---|---|---|---|---|---|
| demographic variables | 1986-1995, % | 1996-2005, % | 2006-2015, % | Total, % | |
| Gender | Male | 51.9 | 50.1 | 51.1 | 50.8 |
| Female | 48 | 49.1 | 48.8 | 48.9 | |
| missing sex | 0.1 | 0.8 | 0.1 | 0.3 | |
| Race | White | 64.1 | 56.5 | 54.7 | 56.8 |
| Black | 34.5 | 39.9 | 38.2 | 38.3 | |
| Latino | 0.6 | 1.8 | 4.2 | 2.8 | |
| Asian | 0.0 | 1.0 | 2.0 | 1.4 | |
| Other | 0.8 | 0.6 | 0.9 | 0.8 | |
| *These are datas for USA population | |||||
Epidemiology of specific glomerular disease
By dividing glomerular diseases into two subtypes, which are Nephrotic or Nephritic, subdividing into several specific disease will be much more easier[1][2] .The incidence of MPGN (as a lesion in renal biopsies) ranges from 1.4 to 9.3 cases per million population (pmp) per year and with few exceptions, the incidence has decreased over time[4]
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| Temporal trends in the renal biopsy frequencies of glomerular disease subtypes among patients with specified glomerular disease diagnoses* | |||||
|---|---|---|---|---|---|
| demographic variables | 1986-1995, % | 1996-2005, % | 2006-2015, % | Total, % | |
| Nephrotic subtypes | FSGS | 22.6 | 27.2 | 24.7 | 25.3 |
| Diabetic glomerulosclerosis | 5.5 | 11.4 | 19.1 | 14.2 | |
| Membranous nephropathy | 17.8 | 13.8 | 10.6 | 12.9 | |
| Minimal change disease | 8.8 | 5.5 | 4.1 | 5.3 | |
| MPGN | 4.5 | 2.9 | 2.5 | 3.0 | |
| Amyloidosis | 2.2 | 2.0 | 2.5 | 2.3 | |
| MIDD | 0.6 | 0.6 | 1.6 | 1.1 | |
| Dense deposit disease | 2.2 | 2.0 | 2.5 | 2.3 | |
| Fabry disease | 0.1 | 0.1 | 0.0 | 0.1 | |
| Collagenofibrotic glomerulopathy | 0.1 | 0.0 | 0.0 | 0.0 | |
| Total | 52.4 | 63.7 | 65.3 | 64.3 | |
| Nephritic subtypes | Lupus nephritis | 12.8 | 13.9 | 11.2 | 12.5 |
| IgAN | 10.2 | 11.4 | 9.4 | 10.3 | |
| ANCA/pauci-immune GN | 9.3 | 6.8 | 8.3 | 7.9 | |
| TBM lesion | 1.9 | 1.3 | 3.0 | 2.2 | |
| Fibrillary GN | 1.5 | 1.2 | 1.4 | 1.4 | |
| Anti-GBM nephritis | 1.1 | 1.0 | 0.8 | 0.9 | |
| Alport syndrome | 0.6 | 0.4 | 0.5 | 0.5 | |
| Immunotactoid GN | 0.2 | 0.1 | 0.1 | 0.1 | |
| Total | 37.6 | 36.3 | 34.7 | 35.7 | |
| *These are datas for USA population | |||||
References
- ↑ 1.0 1.1 Sangeetha Murugapandian, MD, Iyad Mansour, MD, Mohammad Hudeeb, MD, Khaled Hamed, MD, Emad Hammode, MD, Babitha Bijin, MD, Sepehr Daheshpour, MD, Bijin Thajudeen, MD, and Pradeep Kadambi, MD (2016). "Epidemiology of Glomerular Disease in Southern Arizona". Medicine. 95.
- ↑ 2.0 2.1 Michelle M. O’Shaughnessy, Susan L. Hogan, Caroline J. Poulton, Ronald J. Falk, Harsharan K. Singh, Volker Nickeleit, and J. Charles Jennette (2017). "Temporal and Demographic Trends in Glomerular Disease Epidemiology in the Southeastern United States, 1986–2015". Clinical Journal of the American Society of Nephrology. 12.
- ↑ Bassam Alchi & David Jayne (2010). "Membranoproliferative glomerulonephritis". Pediatr Nephrol, Springer.
- ↑ Patrick Maisonneuve, MD, Lawrence Agodoa, MD, Ryszard Gellert, MD, John H. Stewart, MB, Gherardo Buccianti, MD, Albert B. Lowenfels, MD, Robert A. Wolfe, PhD, Elisabeth Jones, MD, Alex P.S. Disney, MD, Douglas Briggs, MD, Margaret McCredie, PhD, and Peter Boyle, PhD. "Distribution of Primary Renal Diseases Leading to End-Stage Renal Failure in the United States, Europe, and Australia/New Zealand: Results From an International Comparative Study". American Journal of Kidney Diseases. 35.