Membranoproliferative glomerulonephritis diagnostic study of choice
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Jogeet Singh Sekhon, M.D. [2] Syed Ahsan Hussain, M.D.[3]
Overview
Renal biopsy is considered the gold standard diagnostic test for MPGN.
Diagnostic study of choice
Study of choice
- Renal biopsy is the gold standard diagnostic test for the diagnosis of membranoproilferative glomerulonephritis[1].
- Light microscopy, electron dense microscopy and immunofluorescence are performed on the renal biopsy sample.
Diagnostic results
Light microscopy
- The findings of glomerulus with increased mesangial cellularity, increase in the mesangial matrix, and thickened peripheral capillary walls are confirmatory for the disease.
Electron microscopy
- Immune deposits in the mesangium and subendothelial space.
Immunoflourescence
- Presence of immunoglobulins or complement in the mesangium depending on the cause.
References
- ↑ Sethi S, Fervenza FC (2012). "Membranoproliferative glomerulonephritis--a new look at an old entity". N Engl J Med. 366 (12): 1119–31. doi:10.1056/NEJMra1108178. PMID 22435371.