Disseminated intravascular coagulation risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]

Overview

Common risk factors in the development of DIC include trauma, sepsis, obstetric complications, cancers, and immunologic reactions

Risk Factors

Common risk factors in the development of DIC include:[1][2]

  • In 2010, the incidence of DIC was estimated to be 26.2 cases per 100,000 individuals worldwide.[3][4][5]
  • Trauma
  • Sepsis
  • Obstetric complications
  • Cancers
  • Immunologic reactions

References

  1. Levi M, Ten Cate H (August 1999). "Disseminated intravascular coagulation". N. Engl. J. Med. 341 (8): 586–92. doi:10.1056/NEJM199908193410807. PMID 10451465.
  2. Sallah S, Wan JY, Nguyen NP, Hanrahan LR, Sigounas G (September 2001). "Disseminated intravascular coagulation in solid tumors: clinical and pathologic study". Thromb. Haemost. 86 (3): 828–33. PMID 11583315.
  3. Singh B, Hanson AC, Alhurani R, Wang S, Herasevich V, Cartin-Ceba R, Kor DJ, Gangat N, Li G (May 2013). "Trends in the incidence and outcomes of disseminated intravascular coagulation in critically ill patients (2004-2010): a population-based study". Chest. 143 (5): 1235–1242. doi:10.1378/chest.12-2112. PMID 23139140.
  4. Smith OP, White B, Vaughan D, Rafferty M, Claffey L, Lyons B, Casey W (November 1997). "Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans". Lancet. 350 (9091): 1590–3. PMID 9393338.
  5. Gando S, Nanzaki S, Kemmotsu O (January 1999). "Disseminated intravascular coagulation and sustained systemic inflammatory response syndrome predict organ dysfunctions after trauma: application of clinical decision analysis". Ann. Surg. 229 (1): 121–7. PMC 1191617. PMID 9923809.


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