Disseminated intravascular coagulation history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

History

Symptoms

Symptoms of DIC vary depending on the magnitude of the imbalance of hemostasis, type of the disease, and the underlying cause. Common manifestations of DIC include bleeding and/or thrombosis with the resulting end organ damage. Patients with acute DIC typically present with bleeding symptoms ranging from oozing from venipuncture sites, petechiae, and ecchymoses; whereas chronic DIC is often associated with hypercoagulable states and thromboembolic complications.

Bleeding Symptoms ^[1]^[2]

Petechiae
Ecchymoses
Blood oozing from wound sites, intravenous lines, catheters, mucosal surfaces
Hemorrhage involving gastrointestinal tract, lungs, or central nervous system

Thrombosis Symptoms

Venous thromboembolism
Arterial thrombosis with tissue or organ ischemia
Cerebral embolism

Organ Dysfunction

Symptoms of acute kidney injury

Decreased urinary output
Edema
Nausea
Fatigue

Symptoms of hepatic dysfunction

Jaundice
Nausea
Abdominal pain and swelling

Symptoms of acute lung injury

Hemoptysis
Dyspnea

Symptoms of neurologic dysfunction

Coma
Delirium
Focal neurologic deficits

Symptoms of adrenal insufficiency

Fatigue
Nausea
Low blood pressure
Altered mental status

References

↑ Siegal T, Seligsohn U, Aghai E, Modan M (February 1978). "Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases". Thromb. Haemost. 39 (1): 122–34. PMID 580488.
↑ Fourrier F, Chopin C, Goudemand J, Hendrycx S, Caron C, Rime A, Marey A, Lestavel P (March 1992). "Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies". Chest. 101 (3): 816–23. PMID 1531791.

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[pmid580488-1] Siegal T, Seligsohn U, Aghai E, Modan M (February 1978). "Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases". Thromb. Haemost. 39 (1): 122–34. PMID 580488.

[pmid1531791-2] Fourrier F, Chopin C, Goudemand J, Hendrycx S, Caron C, Rime A, Marey A, Lestavel P (March 1992). "Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies". Chest. 101 (3): 816–23. PMID 1531791.

[1]

[2]