Hamartoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

Hamartomas may be classified into different types based on their location, such as: lung (most common), heart, hypothalamus, kidneys, or spleen. Other classifications can consider lesion class, dividing hamartomas into 4 different categories, such as: bone-forming, cartilage-forming, fiber-forming, and benign non–matrix-forming.

Classification

Location

Based on the location, hamartomas can be classified into the following types:

Location	Type
Hypothalamus	Hypothalamic hamartoma
CNS	Neurofibromatosis in von Recklinghausen disease Neuroepithelial cells in tuberous sclerosis
Lung	Endobronchial pulmonary hamartoma Parenchymal pulmonary hamartoma Bronchial hamartoma
Heart	Rhabdomyoma
Kidneys	Angiomyolipoma
Spleen	Splenic hamartoma
Skin	Melanocytic nevi

• Lung
  • Endobronchial pulmonary hamartoma
  • Parenchymal pulmonary hamartoma
• Heart
  • Rhabdomyoma
• Hypothalamus
  • Hypothalamic hamartoma
• Kidneys
  • Angiomyolipoma
• Spleen
  • Splenic hamartoma

Lesion class

Based on the lesion class, hamartomas can be classified into the following types:

• Bone-forming tumors

• Cartilage-forming tumors

• Fiber-forming tumors
  • Nonossifying fibroma
  • Fibrous dysplasia
  • Mazabraud syndrome

• Benign non–matrix-forming tumors