Anemia with low reticulocytosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Differentiating Anemia with low reticulocytosis from Other Diseases
To review the differential diagnosis of anemia, click here.
Disease | Genetics | Clinical manifestation | Lab findings | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
History | Symptoms | Signs | Hemolysis | Intrinsic/Extrinsic | Hb concentration | MCV | RDW | Reticulocytosis | Haptoglobin levels | Hepcidin | Iron studies | Specific finding on blood smear | ||||||
Serum iron | Serum Tfr level | Transferrin or TIBC | Ferritin | Transferrin saturation | ||||||||||||||
Iron deficiency anemia[1] | − |
|
− | − | Hypochromic | Microcytic | ↑ | Nl or ↓ | Nl | Nl | ↓ | ↑ | ↑ | ↓ | ↓↓↓ |
| ||
Iron deficiency anemia (early phase)[2] | − |
|
− | − | Normochromic | Normocytic | ↑ | ↓ | Nl | Nl | ↓ | ↑ | ↑ | ↓ | ↓ |
| ||
Lead poisoning[3] | − |
|
|
|
− | − | Hypochromic | Microcytic | Nl | Nl or ↓ | Nl | Nl | Nl to ↓ | Nl | Nl | Nl to ↓ | − | |
Sideroblastic anemia[4] |
|
|
|
|
− | − | Hypochromic | Microcytic | Nl | Nl or ↓ | Nl | Nl | ↑ | Nl | Nl to ↓ | ↑ | − |
|
Disease | Genetics | History | Symptoms | Signs | Hemolysis | Intrinsic/Extrinsic | Hb concentration | MCV | RDW | Reticulocytosis | Haptoglobin levels | Hepcidin | Serum iron | Serum Tfr level | IBC | Ferritin | Transferrin saturation | Specific finding on blood smear |
Anemia of chronic disease[5] | − | − | − | − | Hypochromic | Microcytic | Nl | Nl or ↓ | Nl | ↑ | ↓ | Nl | ↓ | ↑ | − | NA | ||
Thalassemia[6] | α-thalassemia
|
|
α-thalassemia
|
− | − | Hypochromic | Microcytic | Nl |
|
Nl | Nl | Nl to ↑ | Nl | Nl | ↑ | Nl to ↑ |
| |
Aplastic anemia[7] |
|
|
|
− | − | Normochromic | Normocytic | ↑ | ↓ | Nl | Nl | ↓ | ↓ | Nl | ↑ | ↓ |
| |
Disease | Genetics | History | Symptoms | Signs | Hemolysis | Intrinsic/Extrinsic | Hb concentration | MCV | RDW | Reticulocytosis | Haptoglobin levels | Hepcidin | Serum iron | Serum Tfr level | IBC | Ferritin | Transferrin saturation | Specific finding on blood smear |
Folate deficiency[8] |
|
|
|
|
− | − | Anisochromic | Macrocytic | ↑ | ↓ | Nl | Nl | ↑ | ↑ | ↓ | ↑ | ↑ |
|
Vitamin B12 deficiency[9] |
|
|
|
− | − | Anisochromic | Macrocytic | ↑ | ↓ | Nl | Nl | ↑ | ↑ | ↓ | ↑ | ↑ | ||
Orotic aciduria[10] |
|
|
|
|
− | − | Anisochromic | Macrocytic | ↑ | ↓ | Nl | Nl | ↑ | ↑ | ↓ | ↑ | ↑ | NA |
Disease | Genetics | History | Symptoms | Signs | Hemolysis | Intrinsic/Extrinsic | Hb concentration | MCV | RDW | Reticulocytosis | Haptoglobin levels | Hepcidin | Serum iron | Serum Tfr level | IBC | Ferritin | Transferrin saturation | Specific finding on blood smear |
Fanconi anemia[11] |
|
|
|
− | − | Anisochromic | Macrocytic | ↑ | ↓ | Nl | Nl | ↑ | ↑ | ↓ | ↑ | ↑ | ||
Diamond-Blackfan anemia[12] | Mutations in:
|
|
|
|
− | − | Anisochromic | Macrocytic | Nl | ↓ | Nl | Nl | ↑ | ↑ | ↓ | ↑ | ↑ | NA |
Infections[13] | − | Associated with | + | Extrinsic | Normochromic | Normocytic | ↑ | ↑ | ↓ | Nl | Nl | Nl | − | − | − |
|
References
- ↑ Camaschella C (May 2015). "Iron-deficiency anemia". N. Engl. J. Med. 372 (19): 1832–43. doi:10.1056/NEJMra1401038. PMID 25946282.
- ↑ De Andrade Cairo RC, Rodrigues Silva L, Carneiro Bustani N, Ferreira Marques CD (June 2014). "Iron deficiency anemia in adolescents; a literature review". Nutr Hosp. 29 (6): 1240–9. doi:10.3305/nh.2014.29.6.7245. PMID 24972460.
- ↑ Bain BJ (December 2014). "Lead poisoning". Am. J. Hematol. 89 (12): 1141. doi:10.1002/ajh.23852. PMID 25220013.
- ↑ Bottomley SS, Fleming MD (August 2014). "Sideroblastic anemia: diagnosis and management". Hematol. Oncol. Clin. North Am. 28 (4): 653–70, v. doi:10.1016/j.hoc.2014.04.008. PMID 25064706.
- ↑ Roy CN (2010). "Anemia of inflammation". Hematology Am Soc Hematol Educ Program. 2010: 276–80. doi:10.1182/asheducation-2010.1.276. PMID 21239806.
- ↑ Zainal NZ, Alauddin H, Ahmad S, Hussin NH (December 2014). "α-Thalassemia with Haemoglobin Adana mutation: prenatal diagnosis". Malays J Pathol. 36 (3): 207–11. PMID 25500521.
- ↑ Dolberg OJ, Levy Y (2014). "Idiopathic aplastic anemia: diagnosis and classification". Autoimmun Rev. 13 (4–5): 569–73. doi:10.1016/j.autrev.2014.01.014. PMID 24424170.
- ↑ Koike H, Takahashi M, Ohyama K, Hashimoto R, Kawagashira Y, Iijima M, Katsuno M, Doi H, Tanaka F, Sobue G (March 2015). "Clinicopathologic features of folate-deficiency neuropathy". Neurology. 84 (10): 1026–33. doi:10.1212/WNL.0000000000001343. PMID 25663227.
- ↑ Hunt A, Harrington D, Robinson S (September 2014). "Vitamin B12 deficiency". BMJ. 349: g5226. PMID 25189324.
- ↑ Grohmann K, Lauffer H, Lauenstein P, Hoffmann GF, Seidlitz G (April 2015). "Hereditary orotic aciduria with epilepsy and without megaloblastic anemia". Neuropediatrics. 46 (2): 123–5. doi:10.1055/s-0035-1547341. PMID 25757096.
- ↑ Alter BP (2014). "Fanconi anemia and the development of leukemia". Best Pract Res Clin Haematol. 27 (3–4): 214–21. doi:10.1016/j.beha.2014.10.002. PMC 4254647. PMID 25455269.
- ↑ Vlachos A, Blanc L, Lipton JM (June 2014). "Diamond Blackfan anemia: a model for the translational approach to understanding human disease". Expert Rev Hematol. 7 (3): 359–72. doi:10.1586/17474086.2014.897923. PMID 24665981.
- ↑ Bustinduy AL, Parraga IM, Thomas CL, Mungai PL, Mutuku F, Muchiri EM, Kitron U, King CH (March 2013). "Impact of polyparasitic infections on anemia and undernutrition among Kenyan children living in a Schistosoma haematobium-endemic area". Am. J. Trop. Med. Hyg. 88 (3): 433–40. doi:10.4269/ajtmh.12-0552. PMC 3592521. PMID 23324217.