Paroxysmal nocturnal hemoglobinuria history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

History and Symptoms

History

Patients with PNH may have a positive history of:

• Feeling tired/ weak
• Shortness of breath
• Dark colored urine
• Jaundice
• Blood clots
• Difficulty swallowing
• Chest pain
• Abdominal pain
• Headaches
• Confusion
• Dysphagia
• Erectile dysfunction
• Low blood cell counts
• Iron deficiency

Common Symptoms

Common symptoms of [PNH] include:

• Due to hemolysis
  1. fatigue
  2. dyspnea
  3. dark (red/pink/black) colored urine
  4. jaundice

• Due to thrombosis
  1. headaches
  2. confusion
  3. abdominal pain
  4. chest pain

• Due to nitric oxide depletion
  1. dysphagia
  2. chest pain from esophageal spasm
  3. abdominal pain
  4. erectile dysfunction

Less Common Symptoms

Less common symptoms of [PNH] include

• necrotic skin lesions
• abdominal fullness/ distension