Mantle cell lymphoma causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
The exact cause of mantle cell lymphoma has not been clearly identified.
Causes
Mantle cell lymphoma, like most malignancies, results from the acquisition of a combination of (non-inherited) genetic mutations in somatic cells. The typical mutation occurring in mantle cell lymphoma causes the over expression of cyclin D1 which results in uncontrolled growth of B cells leading to lymphoma development. The factors that initiate the genetic alterations are typically not identifiable, and usually occur in people with no particular risk factors for lymphoma development.